Spermidine-Rich Wheat Germ Extract / Spermidine 124-20-9

Spermidine-rich wheat germ extract is a new type of food recognized by the European Commission. Spermidine can support autophagy, a self-cleaning process that occurs in body cells, which is related to a healthy immune system and can also slow down aging. This new ingredient also provides other nutrients, such as folic acid, which plays a role in immune defense, and vitamin E, which protects cells. It is a classic anti-aging ingredient. It also contains high nutritional value of plant protein and fat. Based on the health characteristics of the raw material, it can be applied to product development in the overall health and healthy aging market segments.

Function of Spermidine

① Spermidine is named after it was first extracted from semen.It is a polyamine (made by the polymerization of two or more amino groups);In the human body, there are two main types of polyamines, spermidine and spermine. Polyamines play an important role in cell growth and tissue differentiation.They can bind and stabilize DNA and RNA, regulate the function of enzymes in cells, and also play an antioxidant role.

② Regardless of whether it is an animal or a human, the concentration of spermidine in the body will decrease with age.One of the main reasons is that the activity of polyamine producing enzymes in the body will decrease.In most elderly people, the level of spermidine is low. However, among healthy 90-year-olds and centenarians, spermidine in the tissues still maintains the level of middle-aged people. Studies have also found that in Asian countries, the higher the intake of spermidine, the higher the local life expectancy.

③ Spermidine may play a certain role in the treatment of cancer, cardiovascular diseases, metabolic diseases and neurodegenerative diseases.In mice with cancer, spermidine supplementation can enhance their own immune surveillance, thereby reducing tumor growth. For cardiovascular diseases, epidemiological studies have shown that the more people who consume spermidine, the lower the morbidity and mortality of cardiovascular diseases. A high-sugar and high-fat diet can induce the occurrence of metabolic diseases; while supplementing spermidine on mice on a high-sugar and high-fat diet can prevent obesity and improve glucose tolerance. In the neuropathy of multiple sclerosis, spermidine can reduce the demyelination of neurons caused by autoimmunity.

④ The mechanism by which spermidine works mainly depends on activating the body's autophagy. You should remember that the so-called autophagy is the self-cleaning process of cells—cleaning out unnecessary garbage and reducing the occurrence of cell apoptosis and cancer. Direct injection of spermidine will activate autophagy in the heart, liver and muscles within 4-24 hours. At the same time, the body's metabolism has also entered a state similar to fasting. Oral spermidine supplementation usually triggers autophagy in heart tissue within 2-4 weeks and reverses the problem of insufficient autophagy caused by aging. Moreover, in addition to promoting autophagy, spermidine can also trigger mitochondrial autophagy, thereby promoting the health of mitochondria.

⑤ Spermidine can play a broad-spectrum anti-inflammatory effect, such as inhibiting TNF-α and NFkB, and can relieve fatal sepsis.Part of this effect comes from autophagy, and the other part lies in its direct regulation of immune cells.

⑥ In addition to activating autophagy and anti-inflammatory, spermidine can also open up many important anti-aging channels.On the one hand, it can inhibit mTOR, on the other hand, it can activate AMPK, thus having a comprehensive "anti-aging" effect.

⑦ Interestingly, spermidine may promote hair growth. In in vitro experiments, spermidine can increase the expression of K15 and K19 keratin in hair epithelial stem cells.In 6 days, with a dose of 0.5uM, it can increase the hair shaft by as much as 20%.