PYRROLOQUINOLINE QUINONE (PQQ) 72909-34-3

Function of Pyrroloquinoline quinone (PQQ)

Pyrroloquinoline quinone is short for PQQ. It is a new prosthetic group that can treat heart disease, neurological diseases, protect the liver, and maintain mitochondrial function.

Pyrroloquinoline quinones are widely present in prokaryotes, plants and mammals. It is not only the prosthetic group of many enzymes, but also the function of transferring electrons, protons and chemical groups in enzymatic reactions, and can also stimulate microorganisms. Growth, plant germination, and plant growth.

(1) Protect the heart from oxidative damage
The protective effect of PQQ on the heart is related to its ability to scavenge free radicals. PQQ can eliminate the reactive oxygen species (ROS) produced by hypoxia-reperfusion, and significantly reduce the release of lactate dehydrogenase in the heart. Under the catalysis of flavin reductase, its catalytic product can also reduce the hemoglobin peroxidation state , Eliminate the damage to myocardium caused by hypoxia and reperfusion.

(2) Prevent liver damage
Experimental liver damage in rats caused by toxins such as carbon tetrachloride (CCl), galactosamine, and sulfide acetamide can be prevented by pre-injecting a certain dose of PQQ and its derivatives into the abdominal cavity. PQQ can reduce the generation of ROS caused by liver toxic substances, significantly reduce the levels of serum bilirubin glutamic pyruvic transaminese (GPT) and lactate dehydrogenase, block liver cell necrosis, and does not affect the conventional biochemical indicators of rats (Such as blood sugar, blood urine nitrogen, etc.).

(3) Promote nerve growth and protect the nervous system
Nerve growth factor (NGF) is the first to be discovered and the most thorough research among the neurotrophic factors. It has the dual biological functions of neuron nutrition and neuroprotection, and it can affect the growth, development and differentiation of central and peripheral neurons. , Regeneration and specific expression of biological functions all play important regulatory roles. Experiments show that in vitro, PQQ can stimulate L-M cells and Schwann cells to produce NGF.

(4) Prevent acetaldehyde poisoning
Acetaldehyde is an intermediate metabolite of alcohol in animals. It is toxic. Many people have mutations in the acetaldehyde dehydrogenase gene and insufficiency, which leads to accumulation of acetaldehyde after drinking, causing redness, redness, dizziness and other mild acetaldehyde poisoning reactions.