R-(+)-Lipoic Acid Sodium Salt 176110-81-9

99% up by HPLC

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Product Information

Product name	R-(+)-Lipoic Acid Sodium Salt； R-(+)-Lipoic Acid Sodium； R+ALA sodium salt; R+ALA sodium
CAS No.	176110-81-9
Molecular Formula	C8H13NaO2S2
Molecular Weight	228.31
Quality Standard	R-(+)-Lipoic Acid Sodium ≥ 99.0% by HPLC; R-Alpha Lipoic Acid≥ 80.0% by HPLC
Appearance	Off-white to light-yellow powder

COA

Test Items	Specifications	Results
Appearance	Off-white to light-yellow powder	Conforms
Melting point	230-250°C	Conforms
Solubility(H₂O)	Soluble in water	Conforms
Specific rotation	+85° ～ +105°	+95.3°
Loss on drying	≤ 3.0%	0.8%
Heavy metals	≤ 10 ppm	<10 ppm
Total plate count	≤ 1000 cfu/g	<10 cfu/g
Moulds and yeasts	≤ 100 cfu/g	<10 cfu/g
Escherichia coli	Negative/g	Negative
Salmonella	Negative/10g	Negative
Particle size	100% through 20 mesh 80% through 80 mesh	Conforms
Assay: R-alpha lipoic acid	≥ 80%(External standard)	82.5%
Assay: R-(+)-lipoic acid sodium	≥ 99.0% (Area Normalization)	99.8%
Conclusion	Complies with Enterprise standard

Usage

Core Functions of R-(+)-Lipoic Acid Sodium

1. Potent Antioxidant Activity: As the natural R-enantiomer, it directly participates in mitochondrial energy metabolism, scavenges free radicals, and regenerates other antioxidants (e.g., vitamins C/E, glutathione).

2. Metabolic Regulation: Enhances insulin sensitivity, supporting the management of diabetic neuropathy and metabolic syndrome.

3. Neuroprotection: Crosses the blood-brain barrier to inhibit neuroinflammation and delay cognitive decline (e.g., applications in Alzheimer’s research).

4. Anti-Aging & Skin Health:Inhibits AGEs (advanced glycation end products) and reduces UV-induced skin damage.

5. Bioavailability Superiority: Compared to racemic (D/L) lipoic acid, the R-form achieves 40-50% higher oral absorption and 30% faster peak plasma concentration.

Competitive Advantages of Sinoway’s R-ALA sodium:

1. Cost Efficiency: Localized raw material procurement (e.g., adipic acid, sulfur sources) and continuous flow process optimization enable 20-30% reduction in production costs.

2. Sustainable Production: Utilizes immobilized catalysts and solvent recovery systems to minimize organic waste (compliant with REACH/EPA standards).

Synthesis Breakthroughs: Asymmetric synthesis (e.g., enzymatic resolution) achieves ≥99.5% R-enantiomer purity with <0.1% chiral impurities.

Applications of R+Lipoic Acid Sodium

1. Pharmaceuticals: Injectable formulations for diabetic neuropathy, oral sustained-release tablets.

2. Nutraceuticals: High-absorption antioxidant capsules (combined with CoQ10, NAC).

Cosmeceuticals: Photoaging serums (pH-stable formulas at 5.5–6.5).