Product Information |
Product Name |
Recombinant human epidermal growth factor (rhEGF) ,cottony-stimulating factor, EGF |
CAS No.:. |
62253-63-8 |
INCI Name |
Human Oligopeptide-1 |
Endotoxin Level |
Less than 1EU/μg |
Bioactivity |
1.0x107 IU/mg up |
Quality Standard |
97% up, Cosmetic Grade |
COA of rhEGF 62253-63-8 |
Items |
Specification |
Result |
Assay |
≥98.0% |
98.2% |
Activity unit |
≥6.0×105IU/mg |
7.50×105 IU |
Identification test |
Positive |
Positive |
Appearance |
It is white and aerosols. Added into 1ml distilled water, it can solve quickly. It should not contain insoluble matter seen by naked eyes. |
It is white and aerosols. Added into 1ml distilled water, it can solve quickly. It should not contain insoluble matter seen by naked eyes. |
PH value |
7.2±0.2 |
7.14 |
Water residue |
≤3.0% |
1.93% |
Sterility test |
No bacterial growth |
No bacterial growth |
Abnormal toxicity exp |
The test animals have No abnormal reactions. They keep healthy, and have weight increase. |
The test animals have No abnormal reactions. They keep healthy, and have weight increase. |
Usage |
Use of Epidermal Growth Factor (rhEGF):
EGF secreted by each of us, when we
were in child times the secretion is the highest, and then it decreased with
age increases. Particularly, After 22 years of age, reduced secretion was more
pronounced. When we use cosmetics containing EGF, absorbed through the skin, added EGF of our skin exogenously, so that it can make our skin to
restore the young state.
We use E.coli by genetic engineering
expressed, produced high purity EGF by biological fermentation. It was named Recombinant
human epidermal growth factor (rhEGF). rhEGF have same structure with Human epidermal
growth factor (EGF), it is a 6.2kDa protein.EGF stimulates the proliferation and differentiation of epithelial
cells from skin, the cornea, lung and tracheal tissue and the gastrointestinal
tract. EGF also promotes the
proliferation of fibroblasts and embryonic cells. Thus, EGF plays an important role in wound healing and organogenesis.
EGF is a highly efficient cell
division factor with many other biological effects, which mainly
includes:
1. stimulating the growth and proliferation of skin, cornea and tracheal
epithelium tissue in vivo.
2. Accelerating the healing process of epidermis damage on skin, cornea,
etc.
3. Repressing the gastric acid excretion.
4. Accelerating the proliferation of epithelial cells in human and
animals.
5. Facilitating the biosynthesis of protein, RNA, DNA as well as metabolic
activity in epidermal cells.
First of all, put the EGF dissolved
in distilled water. Wait the temperature of cosmetic cream decreased to below
40 degrees Celsius, then put the dissolved solution into the cream, stir the
cream to full blending them.