Copper Tripeptide-1 89030-95-5

Copper Tripeptide-1 (CAS 89030-95-5) is a stable complex formed by the binding of Tripeptide-1 with copper ions (Cu²⁺), characterized by enhanced biological activity through the incorporation of copper, which confers antioxidant and reparative properties. Its mechanism of action leverages the synergistic effects of copper ions to promote wound healing, reduce inflammation, and neutralize oxidative stress.

1. Superior Tissue Repair and Wound Healing

1) Mechanism: 

- Copper ions (Cu²⁺) act as critical cofactors for repair enzymes (e.g., lysyl oxidase), enhancing collagen and elastin cross-linking to accelerate wound closure.

- Activates fibroblast proliferation, boosting skin regeneration.

2) Applications:

- Post-procedure recovery (e.g., post-laser, microneedling).

- Burn, trauma, and scar repair products (e.g., scar gels).

- Improvement of stretch marks, acne scars, and epidermal damage.     

2. Potent Antioxidant and Anti-Photoaging Effects

1) Mechanism:

- Copper ions enhance antioxidant enzymes (e.g., superoxide dismutase, SOD), neutralizing free radicals and reducing oxidative stress.

- Inhibits matrix metalloproteinase (MMP-1) activity to prevent collagen degradation.

2) Applications:

- Anti-aging serums, post-sun exposure repair formulations.

- Protection against UV-induced photoaging (e.g., wrinkles, hyperpigmentation).      

3. Anti-Inflammatory and Soothing for Sensitive Skin

1) Mechanism:

- Suppresses pro-inflammatory cytokines (e.g., TNF-α, IL-6), reducing skin inflammation.

- Modulates immune cell activity to alleviate redness and irritation.

2) Applications:

- Sensitive skin/rosacea care products.

- Adjuvant therapy for acne, eczema, and inflammatory skin conditions.

4. Promotes Hair Follicle Health and Anti-Hair Loss

1) Mechanism:

- Copper ions stimulate dermal papilla cell proliferation, extending the hair growth phase (anagen).

- Enhances angiogenesis around follicles, improving nutrient supply to the scalp.  

2) Applications:

- Anti-hair loss shampoos, hair growth serums.

- Management of androgenetic alopecia, postpartum hair loss.

5. Strengthens Skin Barrier Function

1) Mechanism:

- Boosts ceramide synthesis to reinforce stratum corneum hydration.

- Upregulates tight junction proteins (e.g., Claudin), reducing transepidermal water loss (TEWL).   2) Applications:

- Dry/sensitive skin moisturizers, barrier-repair emulsions.

- Relief for dryness, flaking, and redness caused by barrier impairment.

6. Synergistic Anti-Aging and Firming Benefits

1) Mechanism:

- Copper ions synergize with the tripeptide to stimulate collagen I/III synthesis, improving skin firmness.

- Promotes glycosaminoglycan production (e.g., hyaluronic acid) to plump the dermal structure.

2) Applications:

- Anti-wrinkle serums, eye creams (targeting nasolabial folds, crow’s feet).

- Enhanced skin elasticity and volume.

7. Clinically Proven Safety Profile

1) Advantages:

- Supported by clinical studies demonstrating low irritation (ideal for post-procedure skin).

- Copper ion concentrations are strictly controlled (0.001%-0.1%) to ensure safety.

2) Target Users: Post-procedure recovery, sensitive skin (non-copper-allergic individuals), mature skin, and hair loss sufferers.

8. Formulation Compatibility (pH-Sensitive)

1) Optimal Conditions:Stable in pH 5-7 formulations; compatible with hyaluronic acid, centella asiatica, and other soothing agents.

2) Avoid:Strong acids (e.g., AHAs, high-dose vitamin C) or chelators (e.g., EDTA), which may destabilize the copper-peptide complex.