Ademetionine 1, 4-butanedisulfonate 101020-79-5

Ademetionine: 50.0 - 54.0% by HPLC; 1,4-butanedisulfonate: 46.0%–49.0% by HPLC

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Product Details

Product Information

Product name	Ademetionine 1, 4-butanedisulfonate;
CAS No.	101020-79-5
Molecular Formula	2(C15H23N6O5S).2(C4H10O6S2).C4H8O6S2
Molecular Weight	1451.63
Quality Standard	Ademetionine: 50.0 - 54.0% by HPLC; 1,4-butanedisulfonate: 46.0%–49.0% by HPLC
Appearance	White to off-white Powder

COA

Test Items	Specifications	Results
Appearance	White to off-white Powder	White crystalline powder
HPLC	The retention time of the major peak corresponds to the reference sample.	Complied
Specific Rotation	+28° ～ +34°	+30°
Water	3.0% MAX	2.2%
PH (0.4% AQUEOUS SOLUTION)	1.8 -2.5	2.2
Residue on ignition	≤ 0.5%	0.3%
Heavy Metals	Not more than 10 ppm	Complied
Content of Ademetionine(HPLC)	50.0 - 54.0%	50.1%
Content of 1,4-butanedisulfonate	46.0%–49.0%	48.6%
S,S-isomer	≥ 60%	77.5%
Related substances(HPLC):
- ADENINE	0.5% MAX.	0.1%
- S-ADENOSYL-L-HOMOCYSTEINE	0.5% MAX.	0.05%
- METHYLTHIOADENOSINE	0.5% MAX.	0.2%
OTHER INDIVIDUAL IMPURITY	0.1% MAX.	0.09%
- TOTAL OTHER IMPURITIES	1.0% MAX.	0.4%
- TOTAL IMPURITIES	2.5% MAX.	0.8%
ASSAY	≥ 97.0%	98.7%
Bacterual endtoxin :	≤ 0.25EU/mg	Complied
Microbiology :
Total Aerobic Count	≤ 200cfu/g	Complied
Total Combined Yeasts and Molds Count	≤ 100cfu/g	Complied
E. coli	Absent/10g	Complied
Conclusion	Complies with Enterprise standard

Usage

Functions of Ademetionine 1,4-Butanedisulfonate

Ademetionine 1,4-butanedisulfonate (SAMe-1,4-BDS) is a stable salt form of S-adenosylmethionine (SAMe), a naturally occurring compound in the human body. Its primary functions include:

1. Liver Health:Promotes hepatocyte regeneration and detoxification. Used to treat liver disorders (e.g., cirrhosis, hepatitis, cholestasis) by enhancing glutathione synthesis and reducing oxidative stress.

2. Neurological and Psychiatric Applications: Modulates neurotransmitter synthesis (e.g., serotonin, dopamine), supporting the treatment of depression, anxiety, and cognitive disorders.

3. Joint Health: Stimulates proteoglycan synthesis in cartilage, aiding in osteoarthritis management.

4. Enhanced Stability: The 1,4-butanedisulfonate salt improves SAMe’s stability and bioavailability, ensuring longer shelf life and better therapeutic efficacy compared to free SAMe.

China holds significant competitive advantages in producing SAMe-1,4-butanedisulfonate:

1. Scalable Production: Large-scale fermentation and chemical synthesis facilities support high-volume output to meet global demand.

2. Advanced Technology: Adoption of cutting-edge biotechnological processes (e.g., microbial fermentation, enzymatic conversion) ensures high-purity SAMe synthesis.

3. Supply Chain Integration: Well-established raw material networks (e.g., methionine, ATP precursors) reduce lead times and production costs.

Customization Capabilities: Flexibility to produce tailored formulations (e.g., injectables, oral tablets) for diverse clinical needs.