Somatostatin acetate 38916-34-6

98% up by HPLC, GMP

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Product Information

Product name	Somatostatin acetate
Alias	Somatostatina, Somatostatine, Somatostatinum, Somatostatin, cyclic, Somatostatin-14, Aminopan, Panhibin, Somiaton
CAS No.	38916-34-6
Molecular Formula	C76H104N18O19S2
Molecular Weight	1637.87
Molecule Structure
Quality Standard	98% up by HPLC, GMP
Appearance	White powder

COA of Somatostatin Acetate

Items	Specification	Results
Appearance	White Powder	Conforms
Purity(HPLC)	> 98%	99.57%
Specific optical rotation (anhydrous and acetic acid-free substance)	-37° to -47°	-41°
Solubility	freely soluble in water and in acetic acid, practically insoluble in methylene chloride	Conforms
Related substances (HPLC)	Total impurities: NMT 2.0% Any impurity: NMT 1.0%	1.3% 0.3%
Water (Karl Fischer)	NMT 8.0 %	6.5%
Acetic acid (HPLC)	3.0% to 15.0 %	8.7%
Bacterial endotoxins	< 10IU/mg	Conforms
Assay (anhydrous and acetic acid-free substance)	95.0% to 104.0%	99.34%
Conclusion	Complies with the standard.

Usage

Function of Somatostatin Acetate

Somatostatin Acetate is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation through its interaction with G protein.

① It can inhibit the secretion of growth hormone, thyroid stimulating hormone, insulin and glucagon.

②It can inhibit the secretion of gastric acid stimulated by the test meal and 5-peptide gastrin, and can inhibit the release of pepsin and gastrin.

③It can significantly reduce visceral blood flow, reduce portal vein pressure, reduce blood flow and pressure of collateral circulation, and reduce liver blood flow.

④Reduce the secretion of the pancreas and the secretion of the small intestine and gallbladder, reduce enzyme activity, and have a protective effect on pancreatic cells.

⑤ It can affect the absorption and nutritional function of the gastrointestinal tract.

Application of Somatostatin Acetate

Somatostatin Acetate can be used for severe and acute gastric and duodenal ulcer bleeding; acute erosive or hemorrhagic gastritis severe and acute bleeding; prevention of post-pancreatic complications after pancreatic surgery; inhibition of pancreas and Adjuvant treatment for severe secretion of leaky duct after upper small intestine surgery; regulating human differentiated gastric cancer cell lines

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