Product Information Product name Isavuconazole CAS No. 241479-67-4 Molecular Formula C22H17F2N5OS Molecular Weight 437.473 Molecular Structure Quality Standard 98% up by HPLC Appearance White to yellow powder COA of Isavuconazole ITEMS STANDARDS RESULTS Appearance White to yellow powder Conforms Identification The peak position of T001-M9 in the test solution was the same as that in the related solution. Conforms Solubility Practically insoluble in water，soluble Conforms Melting point 120℃~126℃ 121.5℃~123.0℃ Specific Optical Rotation [α]D20：-25.0°~-34.0° -29.1° Related substances Any single impurity≤0.5% 0.17% Total impurity ≤1.0% 0.23% Loss on drying ≤1.0% 0.09% Assay ≥ 98% 99.77% Conclusion The above items have been tested according with the Enterprise Standard for the product，the results comply with Specifications . Usage Isavuconazole is a new type of triazole antifungal drug. On the basis of retaining the potent anti-Candida activity of the first-generation triazole drugs, it has enhanced the activity against filamentous fungal infection and is a broad-spectrum antifungal drug. Compared with other azoles, the special molecular structure of isavuconazole sulfate (containing 2 chiral centers) enables the orientation of the triazole ring to engage with the binding pocket of the fungal CYP51 protein, thus giving it a broader antifungal spectrum , including fungi resistant to azoles (such as itraconazole, voriconazole, and posaconazole), have good antibacterial activity. *Products under the patent are only for R&D use