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Calcium folinate 1492-18-8

Calcium folinate 1492-18-8

99% up by HPLC, GMP, DMF
  • Product Details

Product Information


Product name

Calcium folinate

CAS No.

1492-18-8

Molecular Formula

C20H21N7O7.Ca

Molecular Weight

511.507

Molecular Structure


Quality Standard

99% up by HPLC

Appearance

White or light yellow crystalline powder


COA


ANALYSIS

SPECIFICATION

RESULTS

Appearance

White or light yellow crystalline powder

Conforms

Loss on dying

1.0%

0.09%

Residue on ignition

0.5%

0.1%

Total impurities

1.0%

<0.07%

Single impurity

0.5%

0.05%

Assay(by HPLC)

99.0% up

99.7%

Conclusion

The product meets the in-house specification


Usage


What is Calcium folinate?


Calcium folinate (called Folinic acid or calcium leucovorin also) is the calcium salt of 5-formyl tetrahydrofolic acid. It is an active metabolite of folinic acid and an essential coenzyme for nucleic acid synthesis in cytotoxic therapy. Calcium folinate is frequently used to diminish the toxicity and counteract the action of folate antagonists, such as methotrexate.


Folinic acid is a medication used in the treatment of various cancers in combination with 5-FU. It is also commonly used as an antidote to folic acid antagonists such as methotrexate. Folinic acid (leucovorin) is an antidote, chemotherapy modulating agent, and rescue agent for the chemotherapy class of medications.5-FU administration reduces deoxythymidine monophosphate, blocks DNA synthesis, and causes cell death. Calcium folinate stabilizes the complex between 5-FU and thymidylate synthase and thus augments 5-FU cytotoxicity.


*Products under the patent are only for R&D use

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