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 The role of melatonin in certain cancer treatments

The role of melatonin in certain cancer treatments

May 17, 2022
As people age, some spontaneous mutations, or carcinogenesis caused by the endogenous origin, lead to more instability of DNA, thereby weakening resistance to carcinogens or tumor development.

Studies have shown that melatonin（MT, melatonine） inhibits carcinogenesis in human and mouse lymphocytes in vitro, reduces genetic damage in mouse bone marrow, and effectively inhibits the oncogenic mutagenicity of carcinogens. In addition, melatonin can directly act as an antioxidant and directly protect cells from DNA damage, so it plays an important role in fighting cancer.

1. Breast cancer: Melatonin has inhibitory effect on rat mammary carcinogens. In the mammary glands of female virgin mice, melatonin reduced the incidence of variants, as well as the likelihood of mammary hyperplastic lesions. Melatonin can successfully prevent the specificity of epithelial cells and the development of breast cancer, and it can also reduce the proliferation of lymphoid tissue in the breast and prevent the development of lymphoma.
2. Colon cancer: Melatonin inhibits colon tumor development and tumor size, and increases tumor differentiation. It is found that it has a certain beneficial effect on the glucose and lipid metabolism in rats, normalizes their functions, and inhibits the proliferation and apoptosis of colon tumors.
3. Liver cancer: Melatonin inhibits the development of hepatocellular adenomas and adenocarcinomas, and has a certain protective effect on the initial and developmental stages of carcinogenesis, and it exhibits significant anticancer activity in rat liver cancer CTCs.
4. Skin cancer: Studies have shown that the effect of melatonin on the development of two-stage skin cancer in Swiss mice changes, it can not only reduce the number of papilloma, but also reduce the probability of skin cancer.

Melatonin has inhibitory effects on malignancies, and interestingly, lower doses of melatonin appear to be more effective at inhibiting chemical carcinogen-induced lipid peroxidation and tumorigenesis than higher doses of melatonin.
Tags : melatonin cancer treatment melatonine

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