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The mechanism and precautions of melatonin

The mechanism and precautions of melatonin

Jul 19, 2022

Melatonin is one of the hormones secreted by the pineal gland in the brain. It can inhibit the activity of the hypothalamus-pituitary-target axis, reduce the concentration of cortisol in the blood, regulate people's natural sleep, overcome sleep disorders, and improve sleep quality. The secretion of melatonin in the human body has the law of day low and night high, generally reaching a peak around 2 am. As people age, melatonin secretion will be insufficient, resulting in sleep disorders and a series of dysfunctions. Therefore, supplementing melatonin in vitro can maintain the melatonin level in the body in a young state, adjust and restore the circadian rhythm, deepen sleep, improve sleep quality, improve the functional state of the body and delay aging.


Melatonin must not be overdose, but only in the lowest effective dose. Occasional mild insomnia generally requires only 0.3 mg to 1 mg of melatonin supplements per day, according to research at the University of Cleveland Hospital. Overdosing can have adverse consequences, including: Increased insomnia over time Loss of effectiveness, brain receptors become insensitive to melatonin, melatonin supplementation loses its effect, headache, nausea, drowsiness the next day, impact on work performance, decreased body temperature in the elderly, interaction with other drugs, etc.
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