Clinical research on carnosine（L-carnosine, CAS No.: 305-84-0）has focused on its anti-aging and brain-boosting properties.
Regarding general anti-aging effects, several clinical studies have highlighted that carnosine slows the aging process by preventing oxidative damage and glycation. In addition, studies have also shown that carnosine can directly and indirectly inhibit the secretion of inflammatory mediators such as cytokines. Relieving hidden inflammation becomes another major goal, not only because it is an anti-aging approach, but because it helps prevent the development of chronic degenerative diseases such as heart disease, diabetes, and neurodegeneration such as Parkinson’s and Alzheimer’s sexually transmitted diseases. Given its unique effects on the brain, carnosine also acts as an ideal agent for preventing cognitive function and memory decline with age.
Regarding boosting brain function, there are several double-blind placebo-controlled studies investigating carnosine in patients with neurodegenerative diseases. In one study, 42 patients with chronic encephalopathy (a progressive degenerative disease often seen in people with a history of multiple concussions and other types of brain injury) were given carnosine 0.75 g or 2 g daily for a sustained period of time. For 21 days, its efficacy was compared with a placebo. It was found that in the carnosine group, cognitive function was significantly improved and oxidative stress was significantly alleviated.
Another study investigated the efficacy of carnosine in Parkinson's disease patients treated with levodopa (1.5 g daily for 30 days). When carnosine was added to the treatment regimen, neurological symptoms were significantly relieved by 36%, compared to 16% in the control group. Clinical signs of Parkinson's disease, including decreased physical mobility and limb stiffness, were also significantly relieved. This improvement in "daily activities" in Parkinson's patients allows them to lead more autonomous and better quality lives, the study concludes, and the study concluded that carnosine is the key to improving the efficacy of Parkinson's disease and reducing the potential for standard drug therapy. a reasonable way of toxicity.
Carnosine may also help improve brain function in people with autism. In a double-blind placebo-controlled trial of 31 children with autism, carnosine improved expressive and receptive vocabulary and subjectively improved autism scores after 8 weeks at a dose of 800 mg/day.
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