Isavuconazole 241479-67-4

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Product Information

Product name	Isavuconazole
CAS No.	241479-67-4
Molecular Formula	C22H17F2N5OS
Molecular Weight	437.473
Molecular Structure
Quality Standard	98% up by HPLC
Appearance	White to yellow powder

COA of Isavuconazole

ITEMS	STANDARDS	RESULTS
Appearance	White to yellow powder	Conforms
Identification	The peak position of T001-M9 in the test solution was the same as that in the related solution.	Conforms
Solubility	Practically insoluble in water，soluble	Conforms
Melting point	120℃~126℃	121.5℃~123.0℃
Specific Optical Rotation	[α]D20：-25.0°~-34.0°	-29.1°
Related substances	Any single impurity≤0.5%	0.17%
Related substances	Total impurity ≤1.0%	0.23%
Loss on drying	≤1.0%	0.09%
Assay	≥ 98%	99.77%
Conclusion	The above items have been tested according with the Enterprise Standard for the product，the results comply with Specifications .

Usage

Isavuconazole is a new type of triazole antifungal drug. On the basis of retaining the potent anti-Candida activity of the first-generation triazole drugs, it has enhanced the activity against filamentous fungal infection and is a broad-spectrum antifungal drug. Compared with other azoles, the special molecular structure of isavuconazole sulfate (containing 2 chiral centers) enables the orientation of the triazole ring to engage with the binding pocket of the fungal CYP51 protein, thus giving it a broader antifungal spectrum , including fungi resistant to azoles (such as itraconazole, voriconazole, and posaconazole), have good antibacterial activity.

*Products under the patent are only for R&D use