Oxytocin Acetate 50-56-6

98% up by HPLC, USP, EP, CEP

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Product Information

Product name	Oxytocin Acetate
CAS No.	50-56-6
Molecular Formula	C43H66N12O12S2
Molecular Weight	1007.33
Molecule Structure
Quality Standard	98% up by HPLC, USP/EP, CEP
Appearance	White powder

COA of Oxytocin Acetate

Items	Specification	Results
Appearance	White powder	Conforms
Solubility	Soluble in water or 1% acetic acid at a concentration of ≥1mg/ml to give a clear, colorless solution	Conforms
Identity by HPLC	The retention is same with the reference substance	Conforms
Amino acid composition	gly:0.85～1.10 pro:0.85～1.10 leu:0.85～1.10 cys:1.65～2.20 asn:0.85～1.10 gln:0.85～1.10 ile:0.85～1.10 tyr:0.85～1.10	1.02 1.06 1.01 1.88 0.96 1.01 0.99 1.02
pH	3.0～6.0	5.16
Specific optical rotation	c=1,1%hac	-21.2°
Purity	≥98.0%	99.12%
Related substance(by hplc)	total impurities(%)≤2.0% largest single impurity(%)≤1.0%	0.88% 0.55%
Acetate content(by hplc)	≤12.0%	6.7%
Water	≤8%	5.7%
Peptide content (n%)	≥80.0%	87.6%
Bacterial endotoxins	≤70iu/mg	Conforms
Residual organic solvents	acetonitrile ≤0.041%(by gc) dmf ≤0.088%(by gc) meoh ≤0.3% (by gc) tfa ≤0.1% (by hplc) dcm ≤0.06% (by gc) mecn ≤0.041% (by gc)	Conforms
Assay	95%～105%	99.3%
Conclusion	Complies with the standard.

Usage

Function of Oxytocin Acetate

Oxytocin acetate is a peptide hormone, secreted by the posterior pituitary gland, synthesized by the paraventricular nucleus and supraoptic nucleus of the hypothalamus, composed of 9 amino acids, and transported to the neurohypophysis at a rate of 2 mm to 3 mm per day freed. The cysteine (Cys) residues at positions "1" and "6" form a 6-peptide ring structure in the form of disulfide bonds.

(1) Effect on mammary glands: The breast during lactation continuously secretes milk under the action of prolactin, which is stored in the acinar glands of the breast. Oxytocin can shrink the myoepithelial-like cells around the breast acinar, and promote the breast milk with the lactating function.

(2) The effect on the uterus: Oxytocin has a strong effect on promoting the contraction of the uterus, but the pregnant uterus is more sensitive. Estrogen can increase the sensitivity of the uterus to oxytocin, while progesterone does the opposite.

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