Mupirocin 12650-69-0

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Product Information

Product name	Mupirocin
Molecular Formula	C26H44O9
Molecular Weight	500.6222
CAS No.	12650-69-0
Quality Standard	GMP / USP34 / EP6
Appearance	white or off-white powder

COA of Mupirocin

ITEMS		SPECIFICATIONS	RESULT
Appearance		A white or off-white powder	Conforms
Identification(A,B)		Positive	Conforms
Specific Optical Rotation		-20°~ -16°	-18°
Impurity C		Not more than 2.5%	1.6%
Individual impurity		Not more than 1.0%	Conforms
Total impurities		Not more than 4.5%	3.5%
Chlorides		Not more than 0.5%	Conforms
PH		3.0~4.5	3.6
Water		Not more than 1.0%	0.1%
Residual Solvents	Ethyl Acetate	Not more than 500 ppm	Not deteced
	Isobutyl Acetate	Not more than 5000 ppm	5
	Heptane	Not more than 500 ppm	2
	Acetone	Not more than 3000 ppm	15
Assay		93.0-102.0%	98.1%

Usage

Mupirocin is a topical antibiotic for external use, which is a substance produced by Pseudomonas fluorescens culture fluid, namely Pseudomonas A. Its antibacterial effect is mainly by reversibly combining with isoleucine transfer RNA synthetase, preventing isoleucine infiltration, and stopping the synthesis of isoleucine-containing protein in cells to play a bactericidal or bacteriostatic role. Mupirocin shows bacteriostatic effect at very low concentration and bactericidal effect at high concentration. Mupirocin is highly sensitive to various Gram-positive cocci related to skin infections, especially Staphylococcus and Streptococcus. It is also effective against resistant Staphylococcus aureus; Neisseria gonorrhoeae has some antibacterial effect; it is not sensitive to most anaerobic bacteria and normal skin flora. The incidence of drug-resistant mutants in vitro is very low.

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