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Dexamethasone 9,11-epoxide/ 8-DM/ 24916-90-3

Dexamethasone 9,11-epoxide/ 8-DM/ 24916-90-3

99% up by HPLC; Any Other impurities<0.15%

  • Product Details

Product Information


Product name

Dexamethasone 9,11-epoxide/ 8-DM

16alpha-Methyl Epoxide

CAS No.

24916-90-3

Molecular Formula

C22H28O5

Molecular Weight

372.461

Quality Standard

Purity: 99% up by HPLC; Any Other impurities<0.2%

Appearance

Almost white or white crystalline powder


COA

ANALYSIS

SPECIFICATION

RESULTS

Appearance

Almost white or white crystalline powder

Almost white crystalline powder

Identification(HPLC)

The RT of the sample should be concordant with that of the working Standard

Conforms

Loss on drying

0.5%

0.19%

Specific optical rotation

Between +19° to +23°

+20.8°

Related substances by HPLC

Any other impurities 0.2%

0.17%

Purity 99.0%

99.2%

Assay

98.5%

99.4%

Residual solvents

Methanol 3000ppm

117 ppm

Methylene chloride 1000ppm

315 ppm

Conclusion

The sample complies with the Specifications.



Usage


Dexamethasone 9,11-epoxide is a metabolite of dexamethasone, a synthetic corticosteroid. While dexamethasone itself is widely known and used for its anti-inflammatory and immunosuppressive properties, the specific functions and properties of its metabolites, including dexamethasone 9,11-epoxide, are generally less well-documented and studied.

Here are some points about dexamethasone and its metabolites:

1.     Anti-inflammatory Effects: Dexamethasone and its metabolites exert strong anti-inflammatory effects by inhibiting various inflammatory pathways. This includes reducing the production of inflammatory cytokines and inhibiting the activity of immune cells that contribute to inflammation.

2.     Metabolism: When dexamethasone is administered, it undergoes metabolic transformations in the liver. One of these transformations involves the formation of dexamethasone 9,11-epoxide. This metabolite may have distinct or complementary activities compared to the parent compound.

3.     Pharmacodynamics: The biological activity of dexamethasone metabolites can contribute to the overall pharmacological effects of the drug. These metabolites can potentially interact with glucocorticoid receptors or influence other molecular pathways in the body.

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