Product Information |
Product name |
Carmustin |
Molecular Formula |
C5H9Cl2N3O2 |
Molecular Weight |
214.05 |
CAS No. |
154-93-8 |
Quality Standard |
96.0-101.0% up, medical grade |
Appearance |
White powder |
COA of Carmustin |
TEST ITEMS |
SPECIFICATIONS |
RESULTS |
Characteristics |
A YELLOWISH CRYSTALS, OR CRYSTALLINE POWDER. ODOURLESS, VERY SLIGHTLY SOLUBLE IN WATER, FREELY SOLUBLE IN ETHANOL. |
Conforms |
Identification |
1.POSITIVE 2.POSITIVE 3, MAXIMUM ABSORPTION AT THE WAVELENGTH OF 230NM |
Conforms |
MELTING RANGE |
30℃-32℃, MELTS WITH DECOMPOSITION |
30.7℃-31.7℃, MELTS WITH DECOMPOSITION |
LOSS ON DRYING |
≤0.5% |
0.36% |
CLARITY OF SOLUTION |
CLEAR |
CONROMS 0.1 % |
COLOR OF SOLUTION |
< YG5 |
< YG5 |
RESIDUE SOLVENTS 1, DMF 2,EHTANOL 3,ISOPROPYL ALCOHOL |
0.088% MAX 0.5% MAX 0.5% MAX |
< 0.088% < 0.5% < 0.5% |
RELATED SUBSTANCE |
3.0% MAX |
0.62% |
INDIVIDUAL IMPURITY |
1.5% MAX |
0.16% |
RESIDUE ON IGNITION |
0.1% MAX |
0.03% |
HEAVY METALS |
20PPM MAX |
|
Assay(BY UV) |
96.0% - 101.0%, CALCULATED BASED ON DRIED SUBSTANCE |
99.68% |
Usage |
Function of Carmustine
Carmustine is a nitrosourea
alkylating agent. Although it has a chloroethyl group in its structure, its
chemical reaction is different from that of nitrogen mustard. Because it can
penetrate the blood-brain barrier, it is often used for brain tumors and intracranial
metastases.
It is now believed that this product forms isocyanate and diazonium hydroxide through the action of OH- ions under physiological conditions after entering the body. Isocyanates carbamylate proteins, and diazonium hydroxide generates carbanion ions to alkylate biological macromolecules. Isocyanate can inhibit DNA polymerase, inhibit DNA repair and RNA synthesis. This product is a periodic non-specific drug, and it is not completely cross-resistant with general alkylating agents. The resistance of nitrite drugs has little to do with multi-drug resistance genes. This product has high fat solubility. Permeable to the blood-brain barrier, the concentration in cerebrospinal fluid is 50% to 70% of the plasma concentration. It is mainly metabolized in the liver. The metabolites stay in the plasma for several days and still have anticancer effects. They are slowly released after binding to the protein and have a lasting effect.
*Products under the patent are only for R&D use