Research published in the SCI journal "Journal of Molecular and Cellular Cardiology" by the scientific research team of the Cleveland Medical Center in the United States shows that:
Supplementing NAD+ can improve the energy metabolism of myocardial cells, improve heart function and prevent heart failure. This study has confirmed this key role of NAD+ on heart function from two aspects: "lowering NAD+ level" and "raising NAD+ level". "This provides ideas for the prevention of heart failure." said the head of the scientific research team.
Studies have shown that with age, the level of the human body's important protective factor NAD+ gradually declines, and NAD+ is of great significance to energy metabolism, myocardial protection, tissue regeneration and anti-aging. Scientists infer from this that by supplementing NAD+ precursors and increasing the body's NAD+ levels, it may be able to effectively improve the metabolism of myocardial cells, increase the contractility of the heart, and effectively reduce the risk of heart failure.
The research team used genetic means to decrease the level of NAD+ in the mouse model, triggering mitochondrial metabolic dysfunction in cardiomyocytes, and found that experimental animals showed heart failure; then short-term supplementation of NAD+ precursor NMN(Nicotinamide Mononucleotide) to experimental animals reduced the mortality of cardiomyocytes In the end, the survival rate of experimental animals increased by more than 3 times.