In the face of the sun's ultraviolet rays (UV), skin health is threatened at any time. The health of the skin cannot be ignored. New research shows that the use of β-nicotinamide mononucleotide (NMN) has a positive effect on the skin's response to ultraviolet radiation.
Ultraviolet radiation is the invisible part of the spectrum with a wavelength between visible light and X-rays. Ultraviolet radiation can affect skin health in many ways, mainly through oxidative stress. It turns out that one way this can happen is through the essential trace element iron, which plays a vital role in a wide range of key biological processes in all organisms.
Just like rust-the typical reddish-brown oxidizing compound formed by the reaction of iron and oxygen in the presence of water or air humidity-can damage iron-containing materials, such as automobiles, and this oxidized form of iron is toxic to cells. Iron death is a recently described form of regulated cell death that relies on iron oxidation. When iron oxide levels are uncontrolled and out of balance, highly active compounds can cause oxidative stress and damage the health of many tissues and organs, such as the brain, heart, liver, and kidneys.
Studies have shown that mouse and human skin cells exposed to ultraviolet radiation produce a large number of particles related to iron death. In addition, in the group that received repeated UV treatment, the activity of iron death-related genes increased, but the level of antioxidant molecules did not change much.
In the human body, NMN is the precursor of NAD+, which is essential to balance the level of oxidized molecules in the cell. Along these lines, NAD+ is essential in regulating L-glutathione reduced (GSH) and oxidized glutathione levels, making it the center of iron death regulation. Previous studies have shown that restoring NAD+ levels through NMN treatment can exert a protective effect by reducing the level of oxidative stress. During UV exposure to skin cells, supplementation of NMN can normalize NAD+-related oxidation levels, thereby restoring glutathione levels. By recruiting glutathione production, NMN appears to inhibit lipid peroxide accumulation through GPX4.
The researchers used some data to build a model. In this model, ultraviolet radiation causes cellular "rust" accumulation in skin cells. In this state, due to insufficient glutathione, GPX4 cannot completely block the spread of specific oxidizing components. By saving the imbalance of NAD+, NMN reduces the accumulation of oxidative compounds and prevents oxidative stress caused by ultraviolet rays. NMN or iron death inhibitors may become a promising method to deal with oxidative stress caused by ultraviolet light to promote healthy skin.
However, we do not yet understand which method is best? Is it through creams or oral supplements? We will continue to explore.
IPv6 network supported
English
中文
français
Deutsch
русский
español
português
العربية
日本語
한국의
Türkçe
