How To Increase Nad+ Levels?-www.china-sinoway.com

How to increase nad+ levels?

Dec 27, 2021

NAD+ is an essential compound for enzymes to participate in a large number of biochemical reactions. It is considered to be the key to activating enzymes that drive hundreds of different biological processes. In mammalian cells, NAD+ is one of the most abundant molecules, second only to water.

The natural phenomenon of aging will gradually reduce the amount of NAD+ biosynthesis in the body and lead to a series of changes. Therefore, increasing the level of NAD+ can reverse mitochondrial dysfunction and prolong life. However, the molecular weight of NAD+ is too large to be directly absorbed by cells, and even a large amount of supplementation is of no avail.

Studies have found that supplementing with NAD precursors can increase the level of NAD+ in the human body. Although there are only a few human clinical trials, the results of clinical trials have shown that: NAD+ precursor is safe for human doses. So, what exactly are NAD+ precursor supplements? What about absorption efficiency, toxicity and dosage range? Which NAD+ precursor works best?

1. Nicotinamide (NAM)
NAM is one of the first metabolic compounds used to increase NAD+ levels. Since NAM is easily available and can enter cells through cell membranes, this precursor is the most logical candidate for the treatment of NAD+ deficiency in brain tissue. but. NAM can quickly penetrate the blood-brain barrier (BBB), enter from the circulation, and break through the barriers of the nervous system. This shows that NAM can also be quickly lost from tissues with blood.

Research on the tolerance of NAM has shown that it is safe to take 500-1500 mg of NAM per day and long-term intake, but when the dose is higher than 3 grams, it may cause liver toxicity, nephrotoxicity, pancreatic β cell abnormality and other side effects.

2. Nicotinamide ribose (NR)
Another option to increase the level of NAD is to supplement NR. As a dietary supplement to increase NAD+ levels, NR can help cardiovascular health and cause fewer side effects. But NR is very unstable in blood, which makes measurement and detection difficult. Due to its instability, the dosage of NR used in dietary supplements to produce beneficial effects will also be very high.

In addition, published human clinical studies of NR have shown that NR is helpful to increase the level of NAD+ in the body, but the effect of improving physiological functions is poor or almost no.

3. Nicotinamide Mononucleotide (NMN)

Since NMN is the direct precursor of NAD+, in theory, it can more effectively promote the synthesis of NAD+ by bypassing the complicated transformation steps.

In animal experiments, it has been confirmed that oral NMN can quickly supplement NAD+. In the existing human clinical trials used to study NMN, the dose of NMN ranges from 100-1200 mg, and there is no report about the significant adverse effects of NMN on physiological parameters.

4. Niacin (NA)

Niacin is a B vitamin, which is relatively inexpensive and helps maintain the nervous system, digestive system and skin health. Most people can get enough niacin from food. It can be used clinically to treat hyperlipidemia. According to research, daily intake of 1000 to 3000 NA mg can reduce blood triglyceride levels and low-density lipoprotein (LDL), while increasing high-density lipoprotein (HDL) levels, thereby helping to regulate the ratio of low-density lipoprotein HDL.

During the course of the study, daily intake of 750-1000 mg of niacin was shown to increase participants’ NAD+ levels. But at the same time, studies have also found that daily intake of more than 50 mg of niacin will induce skin flushing and gastrointestinal discomfort in most individuals. Serious side effects are reported when taking 2,000 to 6,000 mg of niacin daily. At present, the maximum tolerable limit of NA for adults in the United States and Canada has been set at 35 mg per day, and its clinical use is restricted.

In a word, from all human clinical trials of NAD+, nicotinamide (NAM), niacin (NA) and nicotinamide mononucleotide (NMN) , these three NAD+ precursors can effectively increase the level of NAD+ in the body and improve physiological functions. However, these three NAD+ precursors have their own advantages and disadvantages. Niacinamide (NAM) Niacin (NA) is inexpensive, but overdose may have side effects. Nicotinamide mononucleotide (NMN) has no reports of adverse effects, but the amount of clinical trial data on human studies is not large enough, and the price is high.

Tags : NMN NAD Nicotinamide Mononucleotide

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