Choline alfoscerate (α-GPC; alpha GPC; L-alpha glycerylphosphorylcholine; CAS No.:28319-77-9) is common choline compound and acetycholine precursor in the brain, which has been shown to be effective in the treatment of Alzheimer’s disease and dementia. α-GPC has been shown to enhance memory and cognitive function in stroke and Alzheimer’s patients but currently remains untested in patients suffering from epilepsy. This study aimed to evaluate whether α-GPC treatment after seizure can ameliorate seizure -induced cognitive impairment and neuronal injury.
The potential therapeutic effects of α-GPC on seizure-induced cognitive impairment were tested in an animal model of pilocarpine-induced seizure. Seizures were induced by intraperitoneal injection of pilocarpine (25 mg/ kg) in male rats. α-GPC (250 mg/kg) was injected into the intramuscular space once daily for one or three weeks from immediately after seizure, or from 3 weeks after the seizure onset for 3 weeks. Here we found that immediate 1-week treatment of α-GPC showed no neuroprotective effects and neurogenesis. Immediate 3-week treatment of α-GPC showed neuroprotective effect but no effect on neurogenesis. To evaluate the effect of late treatment of α-GPC on cognitive impairment following seizure, rats were injected α-GPC from 3 weeks after seizure for 3 weeks and subjected to a water maze test. In the present study, we found that administration of αGPC starting at 3 weeks after seizure improved cognitive function through reduced neuronal death and BBB disruption, and increased neurogenesis. Therefore, α-GPC injection may serve as a beneficial treatment forimprovement of cognitive function in epilepsy patients.
Reference:
Late treatment with choline alfoscerate (L-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment
Song Hee Lee, Bo Young Choi, Jin Hee Kim, A.Ra Kho, Min Sohn, Hong Ki Song,Hui Chul Choi
, Sang Won Suha
Department of Physiology, Hallym University, College of Medicine, Chuncheon, Republic of Korea
Department of Neurology, Hallym University, College of Medicine, Chuncheon, Republic of Korea
Inha University, Department of Nursing, Incheon, Republic of Korea
Hallym Institute of Epilepsy Research, Hallym University, College of Medicine, Chuncheon, Republic of Korea
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