Dexamethasone 9,11-epoxide/ 8-DM/ 24916-90-3

99% up by HPLC; Any Other impurities<0.15%

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Product Details

Product Information

Product name	Dexamethasone 9,11-epoxide/ 8-DM 16alpha-Methyl Epoxide
CAS No.	24916-90-3
Molecular Formula	C22H28O5
Molecular Weight	372.461
Quality Standard	Purity: 99% up by HPLC; Any Other impurities<0.2%
Appearance	Almost white or white crystalline powder

COA

ANALYSIS	SPECIFICATION	RESULTS
Appearance	Almost white or white crystalline powder	Almost white crystalline powder
Identification(HPLC)	The RT of the sample should be concordant with that of the working Standard	Conforms
Loss on drying	≤0.5%	0.19%
Specific optical rotation	Between +19° to +23°	+20.8°
Related substances by HPLC	Any other impurities ≤0.2%	0.17%
Related substances by HPLC	Purity ≥ 99.0%	99.2%
Assay	≥ 98.5%	99.4%
Residual solvents	Methanol ≤ 3000ppm	117 ppm
	Methylene chloride ≤ 1000ppm	315 ppm
Conclusion	The sample complies with the Specifications.

Usage

Dexamethasone 9,11-epoxide is a metabolite of dexamethasone, a synthetic corticosteroid. While dexamethasone itself is widely known and used for its anti-inflammatory and immunosuppressive properties, the specific functions and properties of its metabolites, including dexamethasone 9,11-epoxide, are generally less well-documented and studied.

Here are some points about dexamethasone and its metabolites:

1. Anti-inflammatory Effects: Dexamethasone and its metabolites exert strong anti-inflammatory effects by inhibiting various inflammatory pathways. This includes reducing the production of inflammatory cytokines and inhibiting the activity of immune cells that contribute to inflammation.

2. Metabolism: When dexamethasone is administered, it undergoes metabolic transformations in the liver. One of these transformations involves the formation of dexamethasone 9,11-epoxide. This metabolite may have distinct or complementary activities compared to the parent compound.

3. Pharmacodynamics: The biological activity of dexamethasone metabolites can contribute to the overall pharmacological effects of the drug. These metabolites can potentially interact with glucocorticoid receptors or influence other molecular pathways in the body.