Fluralaner 13311-84-7

98% up by HPLC, GMP/ DMF

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Product Details

Product Information

Product name	Fluralaner
CAS No.	13311-84-7
Molecular Formula	C11H11F3N2O3
Molecular Weight	276.215
Quality Standard	98% up by HPLC
Appearance	White or almost white powder

COA

ANALYSIS	SPECIFICATION	RESULTS
Appearance	White or almost white powder	White powder
Solubility	Freely soluble in tetrahydrofuran, methanol, soluble in alcohol, slightly soluble in isopropanol, practically insoluble in hexane.	Conforms
Melting point	172-176°C	176°C
Identification	HPLC retention time conforms to standard.	Conforms
Identification	IR spcctra is consistent with CRS.	Conforms
Water	≤0.5%	0.05%
Residue On lgnition	≤0.1%	0.03%
Heavy metals	≤20ppm	Conforms
Residual Solvents	Tetrahydrofuran ≤ 720ppm
	N-Hexane ≤ 290ppm
	Dichloromethane ≤600ppm
	N,N-Dimethylformamide≤880ppm
	Ethyl Acetate≤5000ppm
	Isopropyl Alcohol≤5000ppm
	Methyl Tert-Butyl Ethel≤5000ppm
	Triethylamine≤5000ppm
Related substance	Impurity A ≤ 0.50%	ND
	Impurity B ≤ 0.50%	0.11%
	Impurity C ≤ 0.50%	0.01%
	Impurity D ≤ 0.50%	ND
	Individual impurity ≤ 0.20%	0.02%
	Total impurities ≤ 2.0%	0.15%
Assay((on dried bases)	98% - 102%	99.5%
Conclusion	The product meets Enterprise Standard

Usage

What is Fluralaner?

Fluralaner is used in veterinary medicine, particularly in products designed to control flea and tick infestations in dogs and cats. It belongs to a class of drugs called isoxazolines, which are known for their potent insecticidal and acaricidal (tick-killing) properties.

Products containing fluralaner are typically administered orally, either as chewable tablets or flavored soft chews. Fluralaner works by interfering with the nervous system of fleas and ticks, ultimately leading to their death. It's effective against various species of ticks and fleas, including the brown dog tick, American dog tick, black-legged tick (deer tick), and lone star tick.

Fluralaner is valued for its long-lasting efficacy, with some formulations providing protection for up to 12 weeks against fleas and ticks after a single dose. It's an important tool in preventing flea and tick-borne diseases in pets and also helps in managing infestations in households where pets are present.

Available intermediates:
- 130336-16-2 (starting material)
- 55860-35-0 (starting material)
- 1171331-39-7 (N-1, side chain)
- 864725-62-2 (N-1, mother nuclear)