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Idebenone 58186-27-9

Idebenone 58186-27-9

98.5% up by HPLC
  • Product Details

Product Information


Product name

Idebenone

CAS No.

58186-27-9

Molecular Formula

C19H30O5

Molecular Weight

338.444

Molecular Structure


Quality Standard

98.5% up by HPLC

Appearance

Orange to yellow crystalline powder


COA


ANALYSIS

SPECIFICATION

RESULTS

Appearance

Orange to yellow crystalline powder

Conforms

Melting range

52-55

Conforms

Loss on drying

0.1%

0.02%

Residue on ignition

0.1%

0.02%

Heavy metals

10ppm

Conforms

Total impurities

0.8%

0.20%

Assay (by HPLC)

98.5%

99.1%

Residue solventies

Hexane 0.029%

0.006%

Methanol 0.30%

ND

Toluene 0.89%

0.0085%

Assay((on dried bases)

98.5% - 101.5%

99.8%

Conclusion

The product meets the standard


Usage


What is Idebenone?


Idebenone (6-[10-hydroxydecil]-2,3-dymethoxy-5-methyl-1,4-benzoquinone) is a quinone analogue, which is used in the treatment of several neurological disorders: Friedreich ataxia (FRDA), mitochondrial encephalomyopathies, senile dementia, and Huntington disease. Idebenone acts as an antioxidant through the action of its quinone ring and diffuses more rapidly than ubiquinone across biological membranes due to the modification of the composition and length of its side chain. Besides being a potent antioxidant, idebenone also functions as an electron transport carrier and has been reported to have various other effects, including stimulation of nerve-growth factor production and blockade of voltage-sensitive calcium channels. Idebenone is rapidly absorbed and has a plasma half-life of 14.9 ± 0.7 h. It crosses the blood–brain barrier. Within 48 h, most of the compound is excreted as metabolites in urine and faeces.


*Products under the patent are only for R&D use

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