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Product Information |
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Product name |
Boc-3-Hydroxy-1-adamantyl-D-glycine / Saxagliptin intermediate |
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CAS No. |
361442-00-4 |
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Molecular Formula |
C17H27NO5 |
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Molecular Weight |
325.405 |
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Quality Standard |
99% up by HPLC |
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Appearance |
White to off-white powder |
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COA of Boc-3-Hydroxy-1-adamantyl-D-glycine |
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ITEMS |
SPECIFICATION |
RESULT |
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Appearance |
White to off-white powder |
Conforms |
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Identification by NMR/LC-MS HPLC |
The retention time of sample is concordant with reference standard |
Conforms |
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Loss on drying |
≤ 1.0% |
0.4% |
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Purity（HPLC） |
≥ 99.0% |
99.67% |
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Conclusion |
The sample confirm to the enterprise standard |
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Usage |
Boc-3-Hydroxy-1-adamantyl-D-glycine is one of key Intermediate of Saxagliptin.
Physical properties about Boc-3-Hydroxy-1-adamantyl-D-glycine are:
(1)ACD/LogP: 1.97;
(2)# of Rule of 5 Violations: 0 ;
(3)#H bond acceptors: 6;
(4)#H bond donors: 3;
(5)#Freely Rotating Bonds: 6;
(6)Polar Surface Area: 95.86 Å2;
(7)Index of Refraction: 1.575;
(8)Molar Refractivity: 82.911 cm3;
(9)Molar Volume: 251.06 cm3;
(10)Polarizability: 32.868 ×10-24cm3;
(11)Surface Tension: 59.817 dyne/cm;
(12)Density: 1.296 g/cm3;
(13)Flash Point: 254.53 °C;
(14)Enthalpy of Vaporization: 88.13 kJ/mol;
(15)Boiling Point: 497.253 °C at 760 mmHg;
(16)Vapour Pressure: 0 mmHg at 25°C.
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